Iron is one of the important trace elements necessary for humans and animals, and an important component for maintaining the body’s special functions. After three stages of development, the ferrous glycinate in the iron nutritional supplement has made up for the shortcomings of the first and second generation iron nutritional supplements. It is the most ideal choice for people.
About iron:
Iron is an important component of hemoglobin, myoglobin and a variety of enzymes. It plays an important role in nutrition and immunity in the body. It is one of the important trace elements necessary for humans and animals, and an important component for maintaining the special functions of the body. In the body, the production of heme, myoglobin, and cytochrome must rely on iron. Iron is directly related to processes such as hematopoiesis, oxygen-carrying, and energy production in animals. The content of iron in the normal human body is 35-60mg/kg, which is higher than the content of several other trace elements.
65% of the iron in the body is in the blood, 70% to 75% of the iron is in the form of heme protein, mainly hemoglobin, myoglobin, and some enzymes cytochrome enzyme, catalase, peroxidase, etc. 20%-30% of the iron is non-heme iron, including ferritin, including transferrin, lactoferrin, uterine ferritin, hemosiderin, and some of the enzymes Huangheyin oxidase and blister acid dehydrogenase and reduced coenzyme dehydrogenase, etc.
Ferritin and hemosiderin are the two basic forms of iron storage, mainly in the liver, reticuloendothelial cells, and bone marrow. The former is water-soluble and suitable for short-term and rapid storage, while the latter is fat-soluble and suitable for longer-term iron storage. Before iron deficiency anemia occurs, stored iron is almost completely depleted.
Iron deficiency anemia is a ubiquitous nutritional deficiency disease worldwide, not only in the vast underdeveloped areas of the world but also in the industrialized world. In many countries, an average of 40% or more women of childbearing age suffers from anemia. According to surveys, there are similar conditions among preschool children.
In a recent study on nutritional intake in the United States, it was found that the average dietary iron intake of women of childbearing age was less than 60% of the recommended daily dietary allowance (RDA) in the United States. The continuous survey of personal food intake in the United States shows that 95% of women aged 20-49 and 95% of infants and children aged 1-2 have iron intakes lower than RDA. Besides, 50% of iron intake in children aged 3-5 is also lower than the RDA.
Although there are nearly a hundred kinds of different oral iron supplements in the world, such as ferrous sulfate, ferrous lactate, ferrous citrate, ferrous gluconate, etc., there are low bioavailability, side effects, inadequacy such as poor absorption efficiency failed to prevent the occurrence of iron deficiency anemia. There are more than 2 billion people in the world who suffer from iron deficiency anemia. In developing countries, they use cereals and beans as their main food, and the absorption of biological iron is low, and absorption is easily hindered. Therefore, the probability of iron deficiency anemia in developing countries is higher than that in developed countries.
Application of ferrous glycinate:
The development of iron nutritional additives has gone through three stages. The first generation is inorganic salts, such as ferrous sulfate and ferrous chloride. The second-generation products are some simple organic compounds, such as ferrous citrate, ferrous fumarate, and so on. The third generation is amino acid chelating iron. The first two types of products have their application disadvantages. Inorganic salts are not only poor in absorption and utilization, but also easily cause environmental pollution, waste of resources, and affect the absorption and utilization of other active nutrients in feed. However, simple organic compounds are still difficult to overcome the shortcomings of low absorption and utilization, and cannot fully meet the needs of animal growth. Therefore, for half a century, animal nutrition scientists have devoted themselves to the research and development of new safe and efficient feed iron additives to overcome the drawbacks of trace element inorganic salt additives.
Glycine is one of the essential nutrients for animals. Animal nutrition researchers use it as a complexing agent to research and develop a new generation of amino acid trace element nutritional additives-ferrous glycinate. Studies have shown that ferrous glycinate has a high biological potency and is a trace element supplement close to the natural form in animals. It can be completely absorbed and utilized by animals and has higher biological absorption than ferrous sulfate and iron EDTA. It has high efficiency and availability, and has almost no reactivity with other foods, has no harm to the body, and is more stable. It has been widely used in the feed and food industries.
The bioavailability of ferrous glycinate is high. Many trace mineral products on the market are too large to be absorbed by the human body because the large molecular particles cannot easily pass through the intestinal wall. The ferrous glycine has a small molecular weight and easily passes through the intestinal wall. And ferrous glycinate is relatively stable in the pH buffer environment, and it remains stable even through the acidic environment of digestion. After entering the plasma, ferrous glycinate remains intact and enters the tissues. At the cellular level of the tissue, it enters an enzyme system and is finally degraded due to changes in stability constants, and then the released atoms are coupled to transferrin with higher stability, and then transported to the blood of the small intestine capillaries.
Traditional compounds, such as ferrous sulfate and ferrous carbonate, must be cracked and reorganized before they can pass through the intestinal wall. During the digestion process, when the iron is separated from its carrier and becomes free radicals, its bioavailability is impaired. These free minerals can easily recombine with other substances to form completely unusable compounds.
Therefore, ferrous glycinate plays an important role in the treatment of various diseases caused by iron deficiency. Ferrous glycinate as an animal feed additive can improve animal nutritional anemia, as a food nutritional additive, it can improve nutritional anemia of children and women and the intellectual development of children. At present, iron deficiency anemia (IDA) blood is still the main concern of governments and health officials. The World Health Organization and many other non-governmental organizations (NGOs) have made urgent recommendations to countries to increase the absorption rate of iron to reduce the incidence. Compared with other iron supplements, ferrous glycinate is undoubtedly the most ideal choice. It has a good taste, low side effects, and a high absorption rate. It has been used for the prevention and treatment of iron deficiency anemia for more than ten years.
